MolNFT v1 · #139267 · protein

Crystal structure of human IMPORTIN4

5XAH · Importin-4: “Crystal structure of human IMPORTIN4”. X-ray diffraction, 11 pockets (best druggability 0.77). MolNFT v1 #139267 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5XAH
Type: protein
Length: 1,491 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin-4
UniProt: Q8TEX9
Pockets: 11 · best druggability 0.77

Structure

x-ray diffraction · 4 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin-4	protein	375	75% helix, 0% strand	Q8TEX9
B	Importin-4	protein	370	80% helix, 0% strand	Q8TEX9
C	Importin-4	protein	376	75% helix, 0% strand	Q8TEX9
D	Importin-4	protein	370	75% helix, 0% strand	Q8TEX9

Pockets

11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	961	0.77	0.79	88	empty
2	97	0.57	0.85	16	empty
3	84	0.48	0.82	22	empty
4	161	0.43	0.74	24	empty
5	107	0.41	0.77	22	empty

Interfaces

4 interfaces between chains.

C–D · 963 Å² buried · 3 hydrogen bonds · protein-protein
B–D · 758 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 548 Å² buried · 4 hydrogen bonds · protein-protein
A–D · 268 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 24 modified (engineered).

Compared structures

5XAH · Crystal structure of human Importin4 · the same entry in another collection · chain D against D, TM-score 1.00
Q8TEX9 · AlphaFold monomer V2.0 prediction for importin-4 (Q8TEX9) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TEX9
Elsewhere: RCSB PDB 5XAH · PDBe 5XAH · UniProt Q8TEX9

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