MolNFT v1 · #139212 · protein

Crystal structure of mouse importin-ALPHA1 bound to the nuclear localization signal of epstein-barr virus ebna-lp protein

5X8N · Importin subunit alpha-1: “Crystal structure of mouse importin-ALPHA1 bound to the nuclear localization signal of epstein-barr virus…”. X-ray diffraction, 1 pocket (best druggability 0.41). MolNFT v1 #139212 on GenesisL1: 3D…

PDB: 5X8N
Type: protein
Length: 433 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; Epstein-barr nuclear antigen leader protein
UniProt: P52293, Q8AZK7
Pockets: 1 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-1	protein	425	73% helix, 0% strand	P52293
B	Epstein-barr nuclear antigen leader protein	protein	8	0% helix, 0% strand	Q8AZK7

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.41	0.81	13	empty

Interfaces

1 interface between chains.

A–B · 814 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

5X8N · Crystal structure of mouse importin-alpha1 bound to the nuclear localization signal of… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Every structure of UniProt Q8AZK7
Elsewhere: RCSB PDB 5X8N · PDBe 5X8N · UniProt P52293 · UniProt Q8AZK7

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