MolNFT v1 · #139083 · protein

Solution structure of the N-terminal domain of tdp-43

5X4F · Tar DNA-binding protein 43: “Solution structure of the N-terminal domain of tdp-43”. Solution nmr, 2 pockets (best druggability 0.35). MolNFT v1 #139083 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5X4F
Type: protein
Length: 77 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tar DNA-binding protein 43
UniProt: Q13148
Pockets: 2 · best druggability 0.35

Structure

solution nmr · 1 distinct chain · 6% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tar DNA-binding protein 43	protein	77	6% helix, 36% strand	Q13148

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.35	0.78	24	empty
2	67	0.32	0.76	17	empty

Compared structures

5X4F · Solution Structure of the N-terminal Domain of TDP-43 · the same entry in another collection · chain A against A, TM-score 1.00
Q13148 · AlphaFold monomer V2.0 prediction for tar DNA-binding protein 43 (Q13148) · a predicted model of the same protein · chain A against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13148
Elsewhere: RCSB PDB 5X4F · PDBe 5X4F · UniProt Q13148

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