MolNFT v1 · #139014 · protein
Crystal structure of EGFR 696-1022 L858R in complex with SKLB(3)
5X26 · Epidermal growth factor receptor: “Crystal structure of EGFR 696-1022 L858R in complex with SKLB(3)”. X-ray diffraction, 2 ligands (7XO, CL), 3 pockets (best druggability 0.61). MolNFT v1 #139014 on GenesisL1: 3D structure, binding…
- PDB
- 5X26
- Type
- protein
- Length
- 302 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epidermal growth factor receptor
- EC
- 2.7.10.1
- UniProt
- P00533
- Ligands
- 7XO, CL
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epidermal growth factor receptor (EC 2.7.10.1) | protein | 302 | 36% helix, 17% strand | P00533 |
Ligands and binding sites
- 7XO · N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-phenyl-9-propan-2-yl-purine-2,8-diamine · ligand · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 346 | 0.61 | 0.78 | 40 | 7XO |
| 2 | 209 | 0.53 | 0.78 | 29 | empty |
| 3 | 77 | 0.36 | 0.76 | 21 | empty |
Compared structures
- 5X26 · Crystal structure of EGFR 696-1022 L858R in complex with SKLB(3) · the same entry in another collection · chain A against A, TM-score 1.00
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Elsewhere: RCSB PDB 5X26 · PDBe 5X26 · UniProt P00533
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.