MolNFT v1 · #138887 · protein

Crystal structure of upa in complex with upain-2-2-W3A

5WXO · Urokinase-type plasminogen activator chain B: “Crystal structure of upa in complex with upain-2-2-W3A”. X-ray diffraction, 1 pocket (best druggability 0.39). MolNFT v1 #138887 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5WXO
Type: protein
Length: 258 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Urokinase-type plasminogen activator chain B; Upain-2-2-W3A peptide
EC: 3.4.21.73
UniProt: P00749
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
U	Urokinase-type plasminogen activator chain B (EC 3.4.21.73)	protein	246	11% helix, 40% strand	P00749
P	Upain-2-2-W3A peptide	protein	12	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	123	0.39	0.74	19	empty

Interfaces

1 interface between chains.

U–P · 671 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide, 1 modified (disulfide, nonstandard).

Compared structures

5WXO · Crystal structure of uPA in complex with upain-2-2-W3A · the same entry in another collection · chain U against U, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00749
Elsewhere: RCSB PDB 5WXO · PDBe 5WXO · UniProt P00749

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