MolNFT v1 · #138886 · protein
Structure of the LKB1 and 14-3-3 complex
5WXN · 14-3-3 protein ZETA/DELTA: “Structure of the LKB1 and 14-3-3 complex”. X-ray diffraction, 3 pockets (best druggability 0.52). MolNFT v1 #138886 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WXN
- Type
- protein
- Length
- 481 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein ZETA/DELTA; SERINE/THREONINE-protein kinase STK11
- UniProt
- P63104, Q15831
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein ZETA/DELTA | protein | 231 | 82% helix, 0% strand | P63104 |
| B | 14-3-3 protein ZETA/DELTA | protein | 230 | 80% helix, 0% strand | P63104 |
| C, D | SERINE/THREONINE-protein kinase STK11 | protein | 10 | 0% helix, 0% strand | Q15831 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.52 | 0.74 | 24 | empty |
| 2 | 71 | 0.36 | 0.77 | 19 | empty |
| 3 | 53 | 0.33 | 0.77 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–C · 855 Ų buried · 20 hydrogen bonds · protein-protein
- B–D · 803 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 765 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 5WXN · Structure of the LKB1 and 14-3-3 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P63104 · AlphaFold monomer V2.0 prediction for 14-3-3 protein ZETA/DELTA (P63104) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q15831 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase STK11 (Q15831) · a predicted model of the same protein · chain C against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63104
- Every structure of UniProt Q15831
- Elsewhere: RCSB PDB 5WXN · PDBe 5WXN · UniProt P63104 · UniProt Q15831
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