MolNFT v1 · #138843 · protein + DNA

The crystal structure of CREN7 mutant L28M in complex with dsdna

5WWC · Chromatin protein CREN7: “The crystal structure of CREN7 mutant L28M in complex with dsdna”. X-ray diffraction, 3 pockets (best druggability 0.54). MolNFT v1 #138843 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5WWC
Type: protein + DNA
Length: 147 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chromatin protein CREN7; DNA (5'-D(*GP*TP*AP*AP*TP*TP*AP*C)-3')
UniProt: Q97ZE3
Pockets: 3 · best druggability 0.54

Structure

x-ray diffraction · 3 distinct chains · 0% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chromatin protein CREN7	protein	56	0% helix, 45% strand	Q97ZE3
B	Chromatin protein CREN7	protein	59	0% helix, 42% strand	Q97ZE3
C, D, E, F	DNA (5'-D(GPTPAPAPTPTPAPC)-3')	dna	8	—	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	225	0.54	0.78	28	empty
2	73	0.32	0.75	12	empty
3	57	0.30	0.76	11	empty

Interfaces

9 interfaces between chains.

B–E · 495 Å² buried · 7 hydrogen bonds · protein-nucleic
A–C · 422 Å² buried · 6 hydrogen bonds · protein-nucleic
B–F · 360 Å² buried · 2 hydrogen bonds · protein-nucleic
E–F · 356 Å² buried · 34 hydrogen bonds · nucleic-nucleic
C–D · 349 Å² buried · 29 hydrogen bonds · nucleic-nucleic

Compared structures

5WWC · The crystal structure of Cren7 mutant L28M in complex with dsDNA · the same entry in another collection · chain F against F, TM-score 1.00
Q97ZE3 · AlphaFold monomer V2.0 prediction for chromatin protein CREN7 (Q97ZE3) · a predicted model of the same protein · chain B against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q97ZE3
Elsewhere: RCSB PDB 5WWC · PDBe 5WWC · UniProt Q97ZE3

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