Research workbench
The crystal structure of CREN7 mutant L28M in complex with dsdna
Analyse The crystal structure of CREN7 mutant L28M in complex with dsdna in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WWC
- Type
- protein + DNA
- Length
- 147 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromatin protein CREN7; DNA (5'-D(*GP*TP*AP*AP*TP*TP*AP*C)-3')
- UniProt
- Q97ZE3
- Pockets
- 3 · best druggability 0.54
Structure
x-ray diffraction · 3 distinct chains · 0% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromatin protein CREN7 | protein | 56 | 0% helix, 45% strand | Q97ZE3 |
| B | Chromatin protein CREN7 | protein | 59 | 0% helix, 42% strand | Q97ZE3 |
| C, D, E, F | DNA (5'-D(*GP*TP*AP*AP*TP*TP*AP*C)-3') | dna | 8 | — | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 225 | 0.54 | 0.78 | 28 | empty |
| 2 | 73 | 0.32 | 0.75 | 12 | empty |
| 3 | 57 | 0.30 | 0.76 | 11 | empty |
Interfaces
9 interfaces between chains.
- B–E · 495 Ų buried · 7 hydrogen bonds · protein-nucleic
- A–C · 422 Ų buried · 6 hydrogen bonds · protein-nucleic
- B–F · 360 Ų buried · 2 hydrogen bonds · protein-nucleic
- E–F · 356 Ų buried · 34 hydrogen bonds · nucleic-nucleic
- C–D · 349 Ų buried · 29 hydrogen bonds · nucleic-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97ZE3
- Elsewhere: RCSB PDB 5WWC · PDBe 5WWC · UniProt Q97ZE3
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