MolNFT v1 · #138817 · protein
Serratia marcescens short-chain DEHYDROGENASE/REDUCTASE F98Y/F202Y mutant
5WVA: “Serratia marcescens short-chain DEHYDROGENASE/REDUCTASE F98Y/F202Y mutant”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #138817 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WVA
- Type
- protein
- Length
- 463 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Short-chain dehydrogenase
- UniProt
- A0A192ICX3
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Short-chain dehydrogenase | protein | 245 | 45% helix, 18% strand | A0A192ICX3 |
| B | Short-chain dehydrogenase | protein | 218 | 41% helix, 21% strand | A0A192ICX3 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 527 | 0.74 | 0.82 | 50 | empty |
| 2 | 319 | 0.57 | 0.76 | 40 | empty |
| 3 | 122 | 0.49 | 0.80 | 27 | empty |
| 4 | 130 | 0.44 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1520 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 5WVA · Serratia marcescens short-chain dehydrogenase/reductase F98Y/F202Y mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A192ICX3
- Elsewhere: RCSB PDB 5WVA · PDBe 5WVA · UniProt A0A192ICX3
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