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Serratia marcescens short-chain DEHYDROGENASE/REDUCTASE F98Y/F202Y mutant

Analyse Serratia marcescens short-chain DEHYDROGENASE/REDUCTASE F98Y/F202Y mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5WVA
Type: protein
Length: 463 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Short-chain dehydrogenase
UniProt: A0A192ICX3
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Short-chain dehydrogenase	protein	245	45% helix, 18% strand	A0A192ICX3
B	Short-chain dehydrogenase	protein	218	41% helix, 21% strand	A0A192ICX3

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	527	0.74	0.82	50	empty
2	319	0.57	0.76	40	empty
3	122	0.49	0.80	27	empty
4	130	0.44	0.77	21	empty

Interfaces

1 interface between chains.

A–B · 1520 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

5WVA · Serratia marcescens short-chain dehydrogenase/reductase F98Y/F202Y mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A192ICX3
Elsewhere: RCSB PDB 5WVA · PDBe 5WVA · UniProt A0A192ICX3

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