MolNFT v1 · #138798 · protein
Crystal structure of mouse importin-ALPHA1 bound to S385- phosphorylated nls of EBNA1
5WUM · Importin subunit alpha-1: “Crystal structure of mouse importin-ALPHA1 bound to S385- phosphorylated nls of EBNA1”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #138798 on GenesisL1: 3D structure, binding sites…
- PDB
- 5WUM
- Type
- protein
- Length
- 440 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Epstein-barr nuclear antigen 1
- UniProt
- P52293, P03211
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 426 | 73% helix, 0% strand | P52293 |
| B | Epstein-barr nuclear antigen 1 | protein | 8 | 0% helix, 0% strand | P03211 |
| C | Epstein-barr nuclear antigen 1 | protein | 6 | 0% helix, 0% strand | P03211 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.43 | 0.82 | 13 | empty |
| 2 | 103 | 0.41 | 0.77 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–C · 588 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 499 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 5WUM · Crystal structure of mouse importin-alpha1 bound to S385-phosphorylated NLS of EBNA1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt P03211
- Elsewhere: RCSB PDB 5WUM · PDBe 5WUM · UniProt P52293 · UniProt P03211
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