MolNFT v1 · #138772 · protein
Crystal structure of human proteasome-assembling chaperone PAC4
5WTQ · Proteasome assembly chaperone 4: “Crystal structure of human proteasome-assembling chaperone PAC4”. X-ray diffraction, 2 ligands (NI, CL), 3 pockets (best druggability 0.59). MolNFT v1 #138772 on GenesisL1: 3D structure, binding…
- PDB
- 5WTQ
- Type
- protein
- Length
- 433 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome assembly chaperone 4
- UniProt
- Q5JS54
- Ligands
- NI, CL
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proteasome assembly chaperone 4 | protein | 114 | 29% helix, 35% strand | Q5JS54 |
| B, D | Proteasome assembly chaperone 4 | protein | 107 | 31% helix, 37% strand | Q5JS54 |
| C | Proteasome assembly chaperone 4 | protein | 105 | 30% helix, 36% strand | Q5JS54 |
Ligands and binding sites
- NI · Nickel (II) ion · metal · 4 copies · chains A, B, C, D
- CL · Chloride ion · ion · 4 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 484 | 0.59 | 0.74 | 48 | empty |
| 2 | 212 | 0.55 | 0.78 | 28 | empty |
| 3 | 212 | 0.54 | 0.78 | 27 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2148 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 2112 Ų buried · 28 hydrogen bonds · protein-protein
- A–C · 339 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5WTQ · Crystal structure of human proteasome-assembling chaperone PAC4 · the same entry in another collection · chain A against A, TM-score 1.00
- Q5JS54 · AlphaFold monomer V2.0 prediction for proteasome assembly chaperone 4 (Q5JS54) · a predicted model of the same protein · chain A against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5JS54
- Elsewhere: RCSB PDB 5WTQ · PDBe 5WTQ · UniProt Q5JS54
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.