MolNFT v1 · #138559 · protein
Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
5WMX: “Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1”. X-ray diffraction, 3 ligands (HEM, ZCW, CYN). MolNFT v1 #138559 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WMX
- Type
- protein
- Length
- 759 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P14902
- Ligands
- HEM, ZCW, CYN
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 380 | — | P14902 |
| B | — | protein | 379 | — | P14902 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
- ZCW · 2-(1H-indol-3-yl)ethanol · ligand · 2 copies · chains A, B
- CYN · Cyanide ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5WMX · Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine… · the same entry in another collection · chain A against A, TM-score 1.00
- P14902 · AlphaFold monomer V2.0 prediction for indoleamine 2,3-dioxygenase 1 (P14902) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14902
- Elsewhere: RCSB PDB 5WMX · PDBe 5WMX · UniProt P14902
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