MolNFT v1 · #138526 · protein
Crystal structure of amino acids 1677-1758 of human beta cardiac myosin fused to XRCC4
5WLZ · DNA repair protein XRCC4,MYOSIN-7: “Crystal structure of amino acids 1677-1758 of human beta cardiac myosin fused to XRCC4”. X-ray diffraction, 7 pockets (best druggability 0.77). MolNFT v1 #138526 on GenesisL1: 3D structure…
- PDB
- 5WLZ
- Type
- protein
- Length
- 794 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA repair protein XRCC4,MYOSIN-7
- UniProt
- Q13426, P12883
- Pockets
- 7 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 52% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | DNA repair protein XRCC4,MYOSIN-7 | protein | 206 | 52% helix, 23% strand | Q13426, P12883 |
| D | DNA repair protein XRCC4,MYOSIN-7 | protein | 200 | 53% helix, 26% strand | Q13426, P12883 |
| A | DNA repair protein XRCC4,MYOSIN-7 | protein | 193 | 50% helix, 26% strand | Q13426, P12883 |
| B | DNA repair protein XRCC4,MYOSIN-7 | protein | 195 | 50% helix, 23% strand | Q13426, P12883 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 976 | 0.77 | 0.79 | 66 | empty |
| 2 | 517 | 0.69 | 0.79 | 48 | empty |
| 3 | 416 | 0.64 | 0.77 | 37 | empty |
| 4 | 164 | 0.45 | 0.75 | 32 | empty |
| 5 | 102 | 0.44 | 0.78 | 14 | empty |
Interfaces
5 interfaces between chains.
- C–D · 2805 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 2648 Ų buried · 16 hydrogen bonds · protein-protein
- C–B · 753 Ų buried · 7 hydrogen bonds · protein-protein
- D–A · 679 Ų buried · 7 hydrogen bonds · protein-protein
- C–A · 301 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5WLZ · Crystal Structure of Amino Acids 1677-1758 of Human Beta Cardiac Myosin Fused to Xrcc4 · the same entry in another collection · chain A against A, TM-score 1.00
- Q13426 · AlphaFold monomer V2.0 prediction for DNA repair protein XRCC4 (Q13426) · a predicted model of the same protein · chain D against A, TM-score 0.89
- P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain C against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13426
- Every structure of UniProt P12883
- Elsewhere: RCSB PDB 5WLZ · PDBe 5WLZ · UniProt Q13426 · UniProt P12883
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