MolNFT v1 · #138439 · protein
Crystal structure of amino acids 1733-1797 of human beta cardiac myosin fused to XRCC4
5WJ7 · DNA repair protein XRCC4,MYOSIN-7: “Crystal structure of amino acids 1733-1797 of human beta cardiac myosin fused to XRCC4”. X-ray diffraction, 2 pockets (best druggability 0.38). MolNFT v1 #138439 on GenesisL1: 3D structure…
- PDB
- 5WJ7
- Type
- protein
- Length
- 391 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA repair protein XRCC4,MYOSIN-7
- UniProt
- Q13426, P12883
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA repair protein XRCC4,MYOSIN-7 | protein | 195 | 51% helix, 26% strand | Q13426, P12883 |
| B | DNA repair protein XRCC4,MYOSIN-7 | protein | 196 | 52% helix, 31% strand | Q13426, P12883 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.38 | 0.77 | 16 | empty |
| 2 | 78 | 0.35 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2437 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 5WJ7 · Crystal Structure of Amino Acids 1733-1797 of Human Beta Cardiac Myosin Fused to Xrcc4 · the same entry in another collection · chain A against A, TM-score 1.00
- Q13426 · AlphaFold monomer V2.0 prediction for DNA repair protein XRCC4 (Q13426) · a predicted model of the same protein · chain B against A, TM-score 0.86
- P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain B against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13426
- Every structure of UniProt P12883
- Elsewhere: RCSB PDB 5WJ7 · PDBe 5WJ7 · UniProt Q13426 · UniProt P12883
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