MolNFT v1 · #138250 · protein
Streptococcus pyogenes phosphoglycerol transferase gach in complex with sn-glycerol-1-phosphate, crystal form 1
5WCX: “Streptococcus pyogenes phosphoglycerol transferase gach in complex with sn-glycerol-1-phosphate, crystal form…”. X-ray diffraction, 3 ligands (1GP, MN, CA), 5 pockets (best druggability 0.72). MolNFT v1 #138250 on GenesisL1: 3D…
- PDB
- 5WCX
- Type
- protein
- Length
- 762 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoglycerol transferase gach
- UniProt
- Q9A0F9
- Ligands
- 1GP, MN, CA
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phosphoglycerol transferase gach | protein | 381 | 43% helix, 16% strand | Q9A0F9 |
Ligands and binding sites
- 1GP · Sn-glycerol-1-phosphate · ligand · 2 copies · chains A, B
- MN · Manganese (II) ion · metal · 2 copies · chains A, B
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 592 | 0.72 | 0.80 | 82 | 1GP |
| 2 | 69 | 0.44 | 0.81 | 24 | empty |
| 3 | 83 | 0.43 | 0.80 | 21 | empty |
| 4 | 84 | 0.40 | 0.78 | 20 | empty |
| 5 | 89 | 0.37 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 954 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 5WCX · Streptococcus pyogenes phosphoglycerol transferase GacH in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9A0F9
- Elsewhere: RCSB PDB 5WCX · PDBe 5WCX · UniProt Q9A0F9
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