MolNFT v1 · #13815 · protein
Crystal structure of the mouse-muscle adenylosuccinate synthetase ligated with GTP
1LOO: “Crystal structure of the mouse-muscle adenylosuccinate synthetase ligated with GTP”. X-ray diffraction, 1 ligand (GTP), 4 pockets (best druggability 0.75). MolNFT v1 #13815 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1LOO
- Type
- protein
- Length
- 431 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylosuccinate synthetase
- EC
- 6.3.4.4
- UniProt
- P28650
- Ligands
- GTP
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylosuccinate synthetase (EC 6.3.4.4) | protein | 431 | 38% helix, 21% strand | P28650 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 981 | 0.75 | 0.78 | 76 | GTP |
| 2 | 190 | 0.52 | 0.77 | 30 | empty |
| 3 | 82 | 0.41 | 0.79 | 15 | empty |
| 4 | 55 | 0.32 | 0.77 | 12 | empty |
Compared structures
- 1LOO · Crystal Structure of the Mouse-Muscle Adenylosuccinate Synthetase Ligated with GTP · the same entry in another collection · chain A against A, TM-score 1.00
- P28650 · AlphaFold monomer V2.0 prediction for adenylosuccinate synthetase isozyme 1 (P28650) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28650
- Elsewhere: RCSB PDB 1LOO · PDBe 1LOO · UniProt P28650
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.