MolNFT v1 · #137996 · protein + RNA
Human IFIT1 dimer with ppp-aaaa
5W5I · Interferon-induced protein with tetratricopeptide repeats 1: “Human IFIT1 dimer with ppp-aaaa”. X-ray diffraction, 11 pockets (best druggability 0.73). MolNFT v1 #137996 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5W5I
- Type
- protein + RNA
- Length
- 874 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon-induced protein with tetratricopeptide repeats 1; RNA…
- UniProt
- P09914
- Pockets
- 11 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon-induced protein with tetratricopeptide repeats 1 | protein | 430 | 75% helix, 0% strand | P09914 |
| B, D | RNA (5'-D(*(ATP))-R(P*AP*AP*A)-3') | rna | 4 | — | — |
| C | Interferon-induced protein with tetratricopeptide repeats 1 | protein | 436 | 75% helix, 0% strand | P09914 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.73 | 0.96 | 26 | empty |
| 2 | 142 | 0.65 | 0.88 | 32 | empty |
| 3 | 294 | 0.62 | 0.79 | 37 | empty |
| 4 | 239 | 0.62 | 0.81 | 29 | empty |
| 5 | 170 | 0.45 | 0.74 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 985 Ų buried · 27 hydrogen bonds · protein-nucleic
- C–D · 978 Ų buried · 28 hydrogen bonds · protein-nucleic
- A–C · 549 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (nucleotide modification).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09914
- Elsewhere: RCSB PDB 5W5I · PDBe 5W5I · UniProt P09914
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