MolNFT v1 · #137963 · protein

Crystal structure of the non-neutralizing and adcc-potent C11-like antibody N12-I3 in complex with HIV-1 clade A/E GP120, the CD4 mimetic M48U1, and the antibody N5-I5.

5W4L: “Crystal structure of the non-neutralizing and adcc-potent C11-like antibody N12-I3 in complex with HIV-1…”. X-ray diffraction, 4 ligands (MPT, NAG, NH2). MolNFT v1 #137963 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5W4L
Type: protein
Length: 2,460 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: A0A0M3KKW9
Ligands: MPT, NAG, NH2, CL

Structure

x-ray diffraction · 8 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
G	—	protein	357	—	A0A0M3KKW9
N, M	—	protein	26	—	—
H, F	—	protein	212	—	—
L, I	—	protein	212	—	—
D, B	—	protein	211	—	—
E	—	protein	213	—	—
A	—	protein	356	—	A0A0M3KKW9
C	—	protein	212	—	—

Ligands and binding sites

MPT · Beta-mercaptopropionic acid · ligand · 2 copies · chains N, M
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 21 copies · chains G, E, A
NH2 · Amino group · ion · 2 copies · chains N, M
CL · Chloride ion · ion · 2 copies · chains G, N, A, M

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5W4L · Crystal structure of the non-neutralizing and ADCC-potent C11-like antibody N12-i3 in… · the same entry in another collection · chain G against G, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0M3KKW9
Elsewhere: RCSB PDB 5W4L · PDBe 5W4L · UniProt A0A0M3KKW9

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