MolNFT v1 · #137952 · protein
The crystal structure of human S-adenosylhomocysteine hydrolase (ahcy) bound to oxadiazole inhibitor
5W49: “The crystal structure of human S-adenosylhomocysteine hydrolase (ahcy) bound to oxadiazole inhibitor”. X-ray diffraction, 2 ligands (NAD, 9W1). MolNFT v1 #137952 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5W49
- Type
- protein
- Length
- 858 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P23526
- Ligands
- NAD, 9W1
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 429 | — | P23526 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains A, B
- 9W1 · (4-amino-1,2,5-oxadiazol-3-yl)[(3R)-3-{4-[(3-methoxyphenyl)amino]-6-methylpyridin-2-yl}pyrrolidin-1-yl]methanone · ligand · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 14 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5W49 · The crystal structure of human S-adenosylhomocysteine hydrolase (AHCY) bound to… · the same entry in another collection · chain A against A, TM-score 1.00
- P23526 · AlphaFold monomer V2.0 prediction for adenosylhomocysteinase (P23526) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23526
- Elsewhere: RCSB PDB 5W49 · PDBe 5W49 · UniProt P23526
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