UniProt P23526
Adenosylhomocysteinase (P23526)
Adenosylhomocysteinase (UniProt P23526), EC 3.3.1.1: 16 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P23526
- Protein
- Adenosylhomocysteinase
- EC
- 3.3.1.1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 2 records with a druggable one
Structures
17 records of P23526 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A7A | Structure of human placental S-adenosylhomocysteine hydrolase: determination of a 30 selenium atom… | x-ray diffraction | A, B | — | — |
| 1A7A | Structure of human placental S-adenosylhomocysteine hydrolase: determination of a 30 selenium atom… | x-ray diffraction | A, B | — | — |
| 1LI4 | Human S-adenosylhomocysteine hydrolase complexed with neplanocin | x-ray diffraction | A | — | — |
| 1LI4 | Human S-adenosylhomocysteine hydrolase complexed with neplanocin | x-ray diffraction | A | — | — |
| 3NJ4 | Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase | x-ray diffraction | A, B, C, D | — | — |
| 3NJ4 | Fluoro-neplanocin a in human S-adenosylhomocysteine hydrolase | x-ray diffraction | A, B, C, D | — | — |
| 4PFJ | The structure of bi-acetylated SAHH | x-ray diffraction | A, B | — | — |
| 4PFJ | The structure of bi-acetylated sahh | x-ray diffraction | A, B | — | — |
| 4PGF | The structure of mono-acetylated SAHH | x-ray diffraction | A, B | — | — |
| 4PGF | The structure of mono-acetylated sahh | x-ray diffraction | A, B | — | — |
| 4YVF | Structure of S-adenosyl-L-homocysteine hydrolase | x-ray diffraction | A, B | — | — |
| 4YVF | Structure of S-adenosyl-L-homocysteine hydrolase | x-ray diffraction | A, B | — | — |
| 5W49 | The crystal structure of human S-adenosylhomocysteine hydrolase (AHCY) bound to oxadiazole inhibitor | x-ray diffraction | A, B | NAD, 9W1 | 6 (best 0.80) |
| 5W49 | The crystal structure of human S-adenosylhomocysteine hydrolase (ahcy) bound to oxadiazole inhibitor | x-ray diffraction | A, B | NAD, 9W1 | — |
| 5W4B | The crystal structure of human S-adenosylhomocysteine hydrolase (AHCY) bound to benzothiazole… | x-ray diffraction | A, B, C, D, E, F | NAD, 9W4 | — |
| 5W4B | The crystal structure of human S-adenosylhomocysteine hydrolase (ahcy) bound to benzothiazole… | x-ray diffraction | A, B, C, D, E, F | NAD, 9W4 | — |
| P23526 | AlphaFold monomer V2.0 prediction for adenosylhomocysteinase (P23526) | predicted | A | — | 4 (best 0.71) |
Ligands
- NAD · Nicotinamide-adenine-dinucleotide · in 4 records
- 9W1 · (4-amino-1,2,5-oxadiazol-3-yl)[(3R)-3-{4-[(3-methoxyphenyl)amino]-6-methylpyridin-2-yl}pyrrolidin-1-yl]methanone · in 2 records
- 9W4 · 4-[(2,5-dioxo-2,5-dihydro-1H-imidazol-1-yl)methyl]-N-[2-(morpholin-4-yl)-1,3-benzothiazol-6-yl]benzamide · in 2 records
Experiment against prediction
- 4PFJ chain A against the predicted model P23526: TM-score 1.00, RMSD 0.23 Å
- 4PFJ chain A against the predicted model P23526: TM-score 1.00, RMSD 0.23 Å
- 4PGF chain A against the predicted model P23526: TM-score 1.00, RMSD 0.30 Å
- 4PGF chain A against the predicted model P23526: TM-score 1.00, RMSD 0.30 Å
- 1LI4 chain A against the predicted model P23526: TM-score 1.00, RMSD 0.32 Å
- 1LI4 chain A against the predicted model P23526: TM-score 1.00, RMSD 0.32 Å
- 1A7A chain B against the predicted model P23526: TM-score 1.00, RMSD 0.33 Å
- 1A7A chain B against the predicted model P23526: TM-score 1.00, RMSD 0.33 Å
- 4PFJ chain B against the predicted model P23526: TM-score 1.00, RMSD 0.33 Å
- 4PFJ chain B against the predicted model P23526: TM-score 1.00, RMSD 0.33 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.