MolNFT v1 · #137582 · protein

Crystal structure of growth differentiation factor

5VT2 · GROWTH/DIFFERENTIATION factor 15: “Crystal structure of growth differentiation factor”. X-ray diffraction. MolNFT v1 #137582 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5VT2
Type: protein
Length: 216 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GROWTH/DIFFERENTIATION factor 15
UniProt: Q99988

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	GROWTH/DIFFERENTIATION factor 15	protein	108	15% helix, 48% strand	Q99988

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 1397 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

5VT2 · Crystal structure of growth differentiation factor · the same entry in another collection · chain A against A, TM-score 1.00
Q99988 · AlphaFold monomer V2.0 prediction for GROWTH/DIFFERENTIATION factor 15 (Q99988) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99988
Elsewhere: RCSB PDB 5VT2 · PDBe 5VT2 · UniProt Q99988

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