UniProt Q99988
Growth/differentiation factor 15 (Q99988)
Growth/differentiation factor 15 (UniProt Q99988): 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99988
- Protein
- Growth/differentiation factor 15
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 11 · 1 record with a druggable one
Structures
9 records of Q99988 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5VT2 | Crystal structure of growth differentiation factor | x-ray diffraction | A, B | — | — |
| 5VT2 | Crystal structure of growth differentiation factor | x-ray diffraction | A, B | — | — |
| 5VZ3 | Growth Factor Crystal Structure at 1.97 Angstrom Resolution | x-ray diffraction | A | — | — |
| 5VZ3 | Growth factor crystal structure at 1.97 ångström resolution | x-ray diffraction | A | — | — |
| 5VZ4 | Receptor-growth factor crystal structure at 2.20 Angstrom resolution | x-ray diffraction | A | BR | 2 (best 0.43) |
| 5VZ4 | Receptor-growth factor crystal structure at 2.20 ångström resolution | x-ray diffraction | A | BR | 2 (best 0.43) |
| 6Q2J | Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15 | electron microscopy | A, B | — | 7 (best 0.58) |
| 6Q2J | Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15 | electron microscopy | A, B | — | — |
| Q99988 | AlphaFold monomer V2.0 prediction for GROWTH/DIFFERENTIATION factor 15 (Q99988) | predicted | A | — | — |
Ligands
- BR · Bromide ion · in 2 records
Experiment against prediction
- 5VT2 chain B against the predicted model Q99988: TM-score 0.97, RMSD 0.79 Å
- 5VT2 chain B against the predicted model Q99988: TM-score 0.97, RMSD 0.79 Å
- 5VZ4 chain A against the predicted model Q99988: TM-score 0.95, RMSD 0.95 Å
- 5VZ4 chain A against the predicted model Q99988: TM-score 0.95, RMSD 0.95 Å
- 5VT2 chain A against the predicted model Q99988: TM-score 0.95, RMSD 0.89 Å
- 5VT2 chain A against the predicted model Q99988: TM-score 0.95, RMSD 0.89 Å
- 5VZ3 chain A against the predicted model Q99988: TM-score 0.94, RMSD 1.04 Å
- 5VZ3 chain A against the predicted model Q99988: TM-score 0.94, RMSD 1.04 Å
- 6Q2J chain B against the predicted model Q99988: TM-score 0.93, RMSD 1.13 Å
- 6Q2J chain B against the predicted model Q99988: TM-score 0.93, RMSD 1.13 Å
Elsewhere
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