MolNFT v1 · #137310 · protein

SPT6 TSH2-RPB1 1476-1500 PS1493

5VKL · Transcription elongation factor SPT6: “SPT6 TSH2-RPB1 1476-1500 PS1493”. X-ray diffraction. MolNFT v1 #137310 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5VKL
Type: protein
Length: 222 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription elongation factor SPT6; DNA-directed RNA polymerase II subunit RPB1
EC: 2.7.7.6
UniProt: P23615, P04050

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription elongation factor SPT6	protein	202	30% helix, 30% strand	P23615
B	DNA-directed RNA polymerase II subunit RPB1 (EC 2.7.7.6)	protein	20	0% helix, 0% strand	P04050

Interfaces

1 interface between chains.

A–B · 1229 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

5VKL · SPT6 tSH2-RPB1 1476-1500 pS1493 · the same entry in another collection · chain A against A, TM-score 1.00
P23615 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT6 (P23615) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23615
Every structure of UniProt P04050
Elsewhere: RCSB PDB 5VKL · PDBe 5VKL · UniProt P23615 · UniProt P04050

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