MolNFT v1 · #137267 · protein
Crystal structure of human zipper-interacting protein kinase (zipk, alias DAPK3) in complex with a PYRAZOLO[3,4-D]PYRIMIDINONE ligand (HS38)
5VJA: “Crystal structure of human zipper-interacting protein kinase (zipk, alias DAPK3) in complex with a…”. X-ray diffraction, 1 ligand (DUK). MolNFT v1 #137267 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5VJA
- Type
- protein
- Length
- 1,059 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O43293
- Ligands
- DUK
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 266 | — | O43293 |
| B | — | protein | 266 | — | O43293 |
| C | — | protein | 265 | — | O43293 |
| D | — | protein | 262 | — | O43293 |
Ligands and binding sites
- DUK · (2R)-2-{[1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide · ligand · 4 copies · chains A, B, C, D
- DMS · Dimethyl sulfoxide · additive · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5VJA · Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in… · the same entry in another collection · chain A against A, TM-score 1.00
- O43293 · AlphaFold monomer V2.0 prediction for death-associated protein kinase 3 (O43293) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43293
- Elsewhere: RCSB PDB 5VJA · PDBe 5VJA · UniProt O43293
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