MolNFT v1 · #137201 · protein

DHX36 with an N-terminal truncation

5VHA · Deah (asp-glu-ala-his) box polypeptide 36: “DHX36 with an N-terminal truncation”. X-ray diffraction, 10 pockets (best druggability 0.83). MolNFT v1 #137201 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5VHA
Type: protein
Length: 810 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Deah (asp-glu-ala-his) box polypeptide 36
UniProt: Q05B79
Pockets: 10 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Deah (asp-glu-ala-his) box polypeptide 36	protein	810	47% helix, 15% strand	Q05B79

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	693	0.83	0.87	88	empty
2	139	0.71	0.91	30	empty
3	176	0.71	0.89	29	empty
4	71	0.56	0.88	19	empty
5	140	0.55	0.82	24	empty

Compared structures

5VHA · DHX36 with an N-terminal truncation · the same entry in another collection · chain A against A, TM-score 1.00
Q05B79 · AlphaFold monomer V2.0 prediction for ATP-dependent DNA/RNA helicase DHX36 (Q05B79) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05B79
Elsewhere: RCSB PDB 5VHA · PDBe 5VHA · UniProt Q05B79

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