MolNFT v1 · #136848 · protein
Structure of NLS2R of influenza a virus nucleoprotein bound to importin alpha
5V5P · Importin subunit alpha-1: “Structure of NLS2R of influenza a virus nucleoprotein bound to importin alpha”. X-ray diffraction, 1 pocket (best druggability 0.47). MolNFT v1 #136848 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5V5P
- Type
- protein
- Length
- 433 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Nucleoprotein
- UniProt
- P52293, Q45VS8
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Importin subunit alpha-1 | protein | 423 | 74% helix, 0% strand | P52293 |
| A, B | Nucleoprotein | protein | 5 | 0% helix, 0% strand | Q45VS8 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.47 | 0.81 | 13 | empty |
Interfaces
2 interfaces between chains.
- C–A · 570 Ų buried · 17 hydrogen bonds · protein-protein
- C–B · 413 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 5V5P · Structure of NLS2R of influenza A virus nucleoprotein bound to importin alpha · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt Q45VS8
- Elsewhere: RCSB PDB 5V5P · PDBe 5V5P · UniProt P52293 · UniProt Q45VS8
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