MolNFT v1 · #136847 · protein

Structure of NLS2K of influenza a virus nucleoprotein bound to importin alpha

5V5O · Importin subunit alpha-1: “Structure of NLS2K of influenza a virus nucleoprotein bound to importin alpha”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #136847 on GenesisL1: 3D structure, binding sites and…

PDB: 5V5O
Type: protein
Length: 436 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; Nucleoprotein
UniProt: P52293
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 3 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Importin subunit alpha-1	protein	423	74% helix, 0% strand	P52293
A	Nucleoprotein	protein	8	0% helix, 0% strand	—
B	Nucleoprotein	protein	5	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.45	0.81	13	empty
2	54	0.38	0.80	21	empty

Interfaces

2 interfaces between chains.

C–A · 705 Å² buried · 23 hydrogen bonds · protein-protein
C–B · 486 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

5V5O · Structure of NLS2K of influenza A virus nucleoprotein bound to importin alpha · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Elsewhere: RCSB PDB 5V5O · PDBe 5V5O · UniProt P52293

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