MolNFT v1 · #136763 · protein
Crystal structure of V71F mutant of the fkbp domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S-farnesyl-L-cysteine methyl ester
5V35: “Crystal structure of V71F mutant of the fkbp domain of human aryl hydrocarbon receptor-interacting…”. X-ray diffraction, 1 ligand (FAR), 2 pockets (best druggability 0.69). MolNFT v1 #136763 on GenesisL1: 3D structure, binding sites…
- PDB
- 5V35
- Type
- protein
- Length
- 152 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1)
- UniProt
- Q9NZN9
- Ligands
- FAR
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) | protein | 152 | 30% helix, 28% strand | Q9NZN9 |
Ligands and binding sites
- FAR · Farnesyl · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.69 | 0.88 | 20 | FAR |
| 2 | 63 | 0.36 | 0.78 | 15 | empty |
Compared structures
- 5V35 · Crystal structure of V71F mutant of the FKBP domain of human aryl hydrocarbon… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NZN9 · AlphaFold monomer V2.0 prediction for aryl-hydrocarbon-interacting protein-like 1 (Q9NZN9) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZN9
- Elsewhere: RCSB PDB 5V35 · PDBe 5V35 · UniProt Q9NZN9
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