MolNFT v1 · #136761 · protein
R. sphaeroides photosythetic reaction center mutant - residue L223, ser to TRP - room temperature structure solved on X-ray transparent microfluidic chip
5V33 · Reaction center protein H chain: “R. sphaeroides photosythetic reaction center mutant - residue L223, ser to TRP - room temperature structure…”. X-ray diffraction, 4 ligands (BCL, BPH, U10), 10 pockets (best druggability 0.82).…
- PDB
- 5V33
- Type
- protein
- Length
- 823 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reaction center protein H chain; Reaction center protein L chain; Reaction center protein…
- UniProt
- P0C0Y7, P0C0Y8, P0C0Y9
- Ligands
- BCL, BPH, U10, FE
- Pockets
- 10 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 51% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Reaction center protein H chain | protein | 240 | 23% helix, 24% strand | P0C0Y7 |
| L | Reaction center protein L chain | protein | 281 | 62% helix, 4% strand | P0C0Y8 |
| M | Reaction center protein M chain | protein | 302 | 64% helix, 4% strand | P0C0Y9 |
Ligands and binding sites
- BCL · Bacteriochlorophyll A · ligand · 4 copies · chains L, M
- BPH · Bacteriopheophytin A · ligand · 2 copies · chains L, M
- U10 · Ubiquinone-10 · ligand · chains H, L, M
- FE · Fe (III) ion · metal · chains L, M
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 820 | 0.82 | 0.84 | 68 | BPH, BCL |
| 2 | 215 | 0.77 | 0.91 | 36 | empty |
| 3 | 76 | 0.70 | 0.95 | 27 | empty |
| 4 | 88 | 0.58 | 0.87 | 17 | empty |
| 5 | 91 | 0.55 | 0.85 | 19 | empty |
Interfaces
3 interfaces between chains.
- L–M · 4611 Ų buried · 63 hydrogen bonds · protein-protein
- H–M · 2890 Ų buried · 39 hydrogen bonds · protein-protein
- H–L · 1599 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 5V33 · R. sphaeroides photosythetic reaction center mutant - Residue L223, Ser to Trp - Room… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0Y7
- Every structure of UniProt P0C0Y8
- Every structure of UniProt P0C0Y9
- Elsewhere: RCSB PDB 5V33 · PDBe 5V33 · UniProt P0C0Y7 · UniProt P0C0Y8 · UniProt P0C0Y9
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