MolNFT v1 · #136693 · protein
Crystal structure of galactoside O-acetyltransferase complex with CoA (P32 space group).
5V0Z · Putative acetyltransferase SACOL2570: “Crystal structure of galactoside O-acetyltransferase complex with CoA (P32 space group).”. X-ray diffraction, 4 ligands (COA, UNX, CL), 3 pockets (best druggability 0.88). MolNFT v1 #136693 on…
- PDB
- 5V0Z
- Type
- protein
- Length
- 567 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative acetyltransferase SACOL2570
- EC
- 2.3.1.-
- UniProt
- Q5HCZ5
- Ligands
- COA, UNX, CL, PO4
- Pockets
- 3 · best druggability 0.88
Structure
x-ray diffraction · 1 distinct chain · 21% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Putative acetyltransferase SACOL2570 (EC 2.3.1.-) | protein | 189 | 21% helix, 29% strand | Q5HCZ5 |
Ligands and binding sites
- COA · Coenzyme A · ligand · 3 copies · chains A, C, B
- UNX · Unknown atom or ion · ion · 31 copies · chains A, C, B
- CL · Chloride ion · ion · 6 copies · chains A, C, B
- PO4 · Phosphate ion · ion · 2 copies · chains A, C
- EDO · 1,2-ethanediol · additive · 5 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 904 | 0.88 | 0.90 | 134 | UNX, CL |
| 2 | 269 | 0.76 | 0.89 | 40 | CL |
| 3 | 75 | 0.75 | 0.98 | 24 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1281 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 1272 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1267 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 5V0Z · Crystal structure of Galactoside O-acetyltransferase complex with CoA (P32 space group). · the same entry in another collection · chain A against A, TM-score 1.00
- Q5HCZ5 · AlphaFold monomer V2.0 prediction for putative acetyltransferase SACOL2570 (Q5HCZ5) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5HCZ5
- Elsewhere: RCSB PDB 5V0Z · PDBe 5V0Z · UniProt Q5HCZ5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.