MolNFT v1 · #136650 · protein
Crystal structure of citrate synthase from homo sapiens
5UZR · Citrate synthase, mitochondrial: “Crystal structure of citrate synthase from homo sapiens”. X-ray diffraction, 1 ligand (CL), 8 pockets (best druggability 0.70). MolNFT v1 #136650 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5UZR
- Type
- protein
- Length
- 869 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Citrate synthase, mitochondrial
- EC
- 2.3.3.1
- UniProt
- O75390
- Ligands
- CL
- Pockets
- 8 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Citrate synthase, mitochondrial (EC 2.3.3.1) | protein | 434 | 63% helix, 6% strand | O75390 |
| D | Citrate synthase, mitochondrial (EC 2.3.3.1) | protein | 435 | 63% helix, 7% strand | O75390 |
Ligands and binding sites
- CL · Chloride ion · ion · 2 copies · chains A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 541 | 0.70 | 0.80 | 54 | CL |
| 2 | 626 | 0.70 | 0.78 | 77 | CL |
| 3 | 181 | 0.57 | 0.81 | 25 | empty |
| 4 | 172 | 0.56 | 0.81 | 26 | empty |
| 5 | 189 | 0.50 | 0.77 | 30 | empty |
Interfaces
1 interface between chains.
- A–D · 4452 Ų buried · 53 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75390
- Elsewhere: RCSB PDB 5UZR · PDBe 5UZR · UniProt O75390
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.