MolNFT v1 · #13652 · protein
Recognition of EIF4G by rotavirus NSP3 reveals a basis for mRNA circularization
1LJ2 · Nonstructural RNA-binding protein 34: “Recognition of EIF4G by rotavirus NSP3 reveals a basis for mRNA circularization”. X-ray diffraction, 1 ligand (AU), 2 pockets (best druggability 0.56). MolNFT v1 #13652 on GenesisL1: 3D…
- PDB
- 1LJ2
- Type
- protein
- Length
- 265 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nonstructural RNA-binding protein 34; Eukaryotic protein synthesis initiation factor
- UniProt
- P03536, Q04637
- Ligands
- AU
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 69% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nonstructural RNA-binding protein 34 | protein | 106 | 78% helix, 3% strand | P03536 |
| B | Nonstructural RNA-binding protein 34 | protein | 110 | 79% helix, 5% strand | P03536 |
| C | Eukaryotic protein synthesis initiation factor | protein | 22 | 32% helix, 14% strand | Q04637 |
| D | Eukaryotic protein synthesis initiation factor | protein | 27 | 19% helix, 33% strand | Q04637 |
Ligands and binding sites
- AU · Gold ion · metal · 3 copies · chains B, A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.56 | 0.89 | 20 | empty |
| 2 | 67 | 0.45 | 0.82 | 16 | empty |
Interfaces
5 interfaces between chains.
- A–B · 3114 Ų buried · 22 hydrogen bonds · protein-protein
- A–D · 549 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 538 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 461 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 334 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1LJ2 · Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization · the same entry in another collection · chain A against A, TM-score 1.00
- Q04637 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4 gamma 1… · a predicted model of the same protein · chain D against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03536
- Every structure of UniProt Q04637
- Elsewhere: RCSB PDB 1LJ2 · PDBe 1LJ2 · UniProt P03536 · UniProt Q04637
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