UniProt Q04637
Eukaryotic translation initiation factor 4 gamma 1 (Q04637)
Eukaryotic translation initiation factor 4 gamma 1 (UniProt Q04637): 17 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 14 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q04637
- Protein
- Eukaryotic translation initiation factor 4 gamma 1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 14 · 3 records with a druggable one
Structures
18 records of Q04637 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LJ2 | Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization | x-ray diffraction | C, D | — | — |
| 1LJ2 | Recognition of EIF4G by rotavirus NSP3 reveals a basis for mRNA circularization | x-ray diffraction | C, D | — | — |
| 1UG3 | C-terminal portion of human eIF4GI | x-ray diffraction | A, B | — | — |
| 1UG3 | C-terminal portion of human EIF4GI | x-ray diffraction | A, B | — | — |
| 2W97 | Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide | x-ray diffraction | E, F | — | — |
| 2W97 | Crystal structure of EIF4E bound to glycerol and EIF4G1 peptide | x-ray diffraction | E, F | — | — |
| 4F02 | Crystal structure of the PABP-binding site of eIF4G in complex with RRM1-2 of PABP and poly(A) | x-ray diffraction | C, F | — | — |
| 4F02 | Crystal structure of the pabp-binding site of EIF4G in complex with RRM1-2 of pabp and POLY(A) | x-ray diffraction | C, F | — | — |
| 5EHC | Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | B | — | — |
| 5EHC | Co-crystal structure of EIF4E with nucleotide mimetic inhibitor. | x-ray diffraction | B | — | — |
| 5T46 | Crystal structure of the human eIF4E-eIF4G complex | x-ray diffraction | B, D | — | 2 (best 0.75) |
| 5T46 | Crystal structure of the human EIF4E-EIF4G complex | x-ray diffraction | B, D | — | — |
| 5ZK5 | Stapled-peptides tailored against initiation of translation | x-ray diffraction | B | — | — |
| 5ZK5 | Stapled-peptides tailored against initiation of translation | x-ray diffraction | B | NH2 | — |
| 8HUJ | Cryo-EM structure of the J-K-St region of EMCV IRES in complex with eIF4G-HEAT1 and eIF4A | electron microscopy | B | — | 7 (best 0.73) |
| 8J7R | Cryo-EM structure of the J-K-St region of EMCV IRES in complex with eIF4G-HEAT1 and eIF4A… | electron microscopy | B | — | 5 (best 0.73) |
| 8OZ0 | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | electron microscopy | 2 | — | — |
| Q04637 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4 gamma 1 (Q04637) | predicted | A | — | — |
Ligands
- NH2 · Amino group · in 1 record
Experiment against prediction
- 1UG3 chain A against the predicted model Q04637: TM-score 0.98, RMSD 1.29 Å
- 1UG3 chain A against the predicted model Q04637: TM-score 0.98, RMSD 1.29 Å
- 8J7R chain B against the predicted model Q04637: TM-score 0.82, RMSD 2.84 Å
- 8HUJ chain B against the predicted model Q04637: TM-score 0.82, RMSD 2.92 Å
- 8OZ0 chain 2 against the predicted model Q04637: TM-score 0.79, RMSD 3.14 Å
- 2W97 chain F against the predicted model Q04637: TM-score 0.69, RMSD 0.38 Å
- 2W97 chain F against the predicted model Q04637: TM-score 0.69, RMSD 0.38 Å
- 5EHC chain B against the predicted model Q04637: TM-score 0.68, RMSD 0.40 Å
- 5EHC chain B against the predicted model Q04637: TM-score 0.68, RMSD 0.40 Å
- 2W97 chain E against the predicted model Q04637: TM-score 0.68, RMSD 0.41 Å
Elsewhere
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