MolNFT v1 · #136473 · protein
Insulin with proline analog thiop at position B28 in the R6 state
5UU4 · Insulin a chain: “Insulin with proline analog thiop at position B28 in the R6 state”. X-ray diffraction, 3 ligands (IPH, ZN, CL). MolNFT v1 #136473 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5UU4
- Type
- protein
- Length
- 94 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin a chain; Insulin B chain
- UniProt
- P01308
- Ligands
- IPH, ZN, CL
Structure
x-ray diffraction · 4 distinct chains · 57% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin a chain | protein | 21 | 48% helix, 5% strand | P01308 |
| B | Insulin B chain | protein | 27 | 63% helix, 11% strand | P01308 |
| C | Insulin a chain | protein | 20 | 45% helix, 15% strand | P01308 |
| D | Insulin B chain | protein | 26 | 69% helix, 12% strand | P01308 |
Ligands and binding sites
- IPH · Phenol · ligand · 2 copies · chains A, B, C, D
- ZN · Zinc ion · metal · 2 copies · chains B, D
- CL · Chloride ion · ion · 2 copies · chains B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
4 interfaces between chains.
- B–D · 662 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 526 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 477 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 30 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 modified (disulfide, nonstandard).
Compared structures
- 5UU4 · Insulin with proline analog ThioP at position B28 in the R6 state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 5UU4 · PDBe 5UU4 · UniProt P01308
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