MolNFT v1 · #136408 · protein
Crystal structure of aminoglycoside acetyltransferase AAC(2')-ia in complex with N2'-acetylgentamicin C1A and coenzyme a
5US1: “Crystal structure of aminoglycoside acetyltransferase AAC(2')-ia in complex with N2'-acetylgentamicin C1A and…”. X-ray diffraction, 3 ligands (8MM, COA, ACO). MolNFT v1 #136408 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5US1
- Type
- protein
- Length
- 2,163 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q52424
- Ligands
- 8MM, COA, ACO
Structure
x-ray diffraction · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 189 | — | Q52424 |
| B, H, I, L | — | protein | 178 | — | Q52424 |
| C | — | protein | 185 | — | Q52424 |
| D, G | — | protein | 177 | — | Q52424 |
| E, K | — | protein | 184 | — | Q52424 |
| F | — | protein | 176 | — | Q52424 |
| J | — | protein | 179 | — | Q52424 |
Ligands and binding sites
- 8MM · (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-(acetylamino)-6-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranoside · ligand · 10 copies · chains A, B, D, E, F, G, H, I, K, L
- COA · Coenzyme A · ligand · 3 copies · chains B, E, J, I, L
- ACO · Acetyl coenzyme *A · ligand · chains C, F, G
- TAR · D(-)-tartaric acid · additive · 5 copies · chains A, D, F, H, J
- GOL · Glycerol · additive · 3 copies · chains C, I, K
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5US1 · Crystal structure of aminoglycoside acetyltransferase AAC(2')-Ia in complex with… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q52424
- Elsewhere: RCSB PDB 5US1 · PDBe 5US1 · UniProt Q52424
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