MolNFT v1 · #136404 · protein
Insulin with proline analog dhp at position B28 in the R6 state
5URU · Insulin chain a: “Insulin with proline analog dhp at position B28 in the R6 state”. X-ray diffraction, 3 ligands (IPH, ZN, CL). MolNFT v1 #136404 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5URU
- Type
- protein
- Length
- 194 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin chain a; Insulin chain B
- UniProt
- P01308
- Ligands
- IPH, ZN, CL
Structure
x-ray diffraction · 3 distinct chains · 70% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Insulin chain a | protein | 21 | 57% helix, 5% strand | P01308 |
| B, H | Insulin chain B | protein | 28 | 75% helix, 11% strand | P01308 |
| D, F | Insulin chain B | protein | 27 | 74% helix, 11% strand | P01308 |
Ligands and binding sites
- IPH · Phenol · ligand · 4 copies · chains A, B, C, D, E, F, G, H
- ZN · Zinc ion · metal · 4 copies · chains B, D, F, H
- CL · Chloride ion · ion · 4 copies · chains B, D, F, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
10 interfaces between chains.
- B–D · 630 Ų buried · 9 hydrogen bonds · protein-protein
- F–H · 623 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 568 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 568 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 535 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide, 4 modified (disulfide, nonstandard).
Compared structures
- 5URU · Insulin with proline analog DhP at position B28 in the R6 state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 5URU · PDBe 5URU · UniProt P01308
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