Crystal structure of the prototype foamy virus intasome with a 2- pyridinone aminal inhibitor (compound 18)

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• 8G4 · (1S,2S,5R)-8'-[(3-chloro-4-fluorophenyl)methyl]-2'-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]-6'-hydroxy-9',10'-dihydro-2'H-spiro[bicyclo[3.1.0]hexane-2,3'-imidazo[5,1-a][2,6]naphthyridine]-1',5',7'(8'H)-trione · ligand · chains A, C, D
• MG · Magnesium ion · metal · 3 copies · chains A, B
• ZN · Zinc ion · metal · chains A
• SO4 · Sulfate ion · ion · 3 copies · chains A, B
• GOL · Glycerol · additive · 5 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5UOP · Crystal structure of the prototype foamy virus intasome with a 2- pyridinone aminal… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P14350
• Elsewhere: RCSB PDB 5UOP · PDBe 5UOP · UniProt P14350