MolNFT v1 · #136300 · protein
The structure of the MAP kinase P38 at 2.1 ångströms resolution
5UOJ · Mitogen-activated protein kinase 14: “The structure of the MAP kinase P38 at 2.1 ångströms resolution”. X-ray diffraction, 5 pockets (best druggability 0.65). MolNFT v1 #136300 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5UOJ
- Type
- protein
- Length
- 343 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 14
- EC
- 2.7.11.24
- UniProt
- P47811
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 343 | 40% helix, 15% strand | P47811 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 399 | 0.65 | 0.78 | 40 | empty |
| 2 | 141 | 0.43 | 0.75 | 26 | empty |
| 3 | 100 | 0.40 | 0.76 | 17 | empty |
| 4 | 87 | 0.33 | 0.74 | 21 | empty |
| 5 | 51 | 0.27 | 0.74 | 16 | empty |
Compared structures
- 5UOJ · The structure of the MAP kinase P38 at 2.1 ångströms resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47811
- Elsewhere: RCSB PDB 5UOJ · PDBe 5UOJ · UniProt P47811
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