Structure of human endothelial nitric oxide synthase heme domain in complex with 3-[(2-amino-4-methylquinolin-7-YL)METHOXY]-5- ((METHYLAMINO)METHYL)BENZONITRILE

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• 8EY · 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile · ligand · 4 copies · chains A, B
• HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
• ZN · Zinc ion · metal · 3 copies · chains A, B
• GD · Gadolinium atom · metal · 2 copies · chains B
• CL · Chloride ion · ion · 2 copies · chains A, B
• BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · 8 copies · chains A, B
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5UOA · Structure of human endothelial nitric oxide synthase heme domain in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

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• Elsewhere: RCSB PDB 5UOA · PDBe 5UOA · UniProt P29474