MolNFT v1 · #136270 · protein
Structure of CDC2-like kinase 2 (CLK2) in complex with compound T-025 [N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-PYRROLO[2, 3-D]PYRIMIDINE-2,4-diamine]
5UNP: “Structure of CDC2-like kinase 2 (CLK2) in complex with compound T-025…”. X-ray diffraction, 1 ligand (8FY). MolNFT v1 #136270 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5UNP
- Type
- protein
- Length
- 694 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P49760
- Ligands
- 8FY
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 347 | — | P49760 |
Ligands and binding sites
- 8FY · N~2~-methyl-N~4~-[(pyrimidin-2-yl)methyl]-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5UNP · Structure of CDC2-Like Kinase 2 (CLK2) in Complex with Compound T-025… · the same entry in another collection · chain A against A, TM-score 1.00
- P49760 · AlphaFold monomer V2.0 prediction for dual specificity protein kinase CLK2 (P49760) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49760
- Elsewhere: RCSB PDB 5UNP · PDBe 5UNP · UniProt P49760
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