UniProt P49760
Dual specificity protein kinase CLK2 (P49760)
Dual specificity protein kinase CLK2 (UniProt P49760), EC 2.7.12.1: 9 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P49760
- Protein
- Dual specificity protein kinase CLK2
- EC
- 2.7.12.1
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 4 · 2 records with a druggable one
Structures
10 records of P49760 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3NR9 | Structure of human CDC2-like kinase 2 (CLK2) | x-ray diffraction | A, B, C | — | — |
| 3NR9 | Structure of human CDC2-like kinase 2 (CLK2) | x-ray diffraction | A, B, C | — | — |
| 5UNP | Structure of CDC2-like kinase 2 (CLK2) in complex with compound T-025… | x-ray diffraction | A, B | 8FY | — |
| 6FYI | X-ray Structure of CLK2-KD(130-496)/TG003 at 2.6A | x-ray diffraction | A | EAE | 2 (best 0.64) |
| 6FYI | X-ray structure of CLK2-KD(130-496)/TG003 at 2.6A | x-ray diffraction | A | EAE | — |
| 6FYK | X-ray structure of CLK2-KD(136-496)/INDAZOLE1 at 2.39A | x-ray diffraction | A, B, C | EAZ | — |
| 6FYL | X-ray structure of CLK2-KD(136-496)/CX-4945 at 1.95A | x-ray diffraction | A | 3NG | 2 (best 0.63) |
| 6FYL | X-ray structure of CLK2-KD(136-496)/CX-4945 at 1.95A | x-ray diffraction | A | 3NG | — |
| 6KHE | Crystal structure of CLK2 in complex with cx-4945 | x-ray diffraction | A | 3NG | — |
| P49760 | AlphaFold monomer V2.0 prediction for dual specificity protein kinase CLK2 (P49760) | predicted | A | — | — |
Ligands
- 3NG · 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid · in 3 records
- EAE · (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one · in 2 records
- 8FY · N~2~-methyl-N~4~-[(pyrimidin-2-yl)methyl]-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine · in 1 record
- EAZ · (2~{S})-4-methyl-1-[5-(3-methyl-2~{H}-indazol-5-yl) pyridin-3-yl]oxy-pentan-2-amine · in 1 record
Experiment against prediction
- 6FYI chain A against the predicted model P49760: TM-score 0.99, RMSD 0.80 Å
- 6FYI chain A against the predicted model P49760: TM-score 0.99, RMSD 0.80 Å
- 6FYL chain A against the predicted model P49760: TM-score 0.99, RMSD 0.85 Å
- 6FYL chain A against the predicted model P49760: TM-score 0.99, RMSD 0.85 Å
- 6KHE chain A against the predicted model P49760: TM-score 0.98, RMSD 0.89 Å
- 5UNP chain B against the predicted model P49760: TM-score 0.98, RMSD 1.36 Å
- 5UNP chain A against the predicted model P49760: TM-score 0.98, RMSD 1.36 Å
- 3NR9 chain A against the predicted model P49760: TM-score 0.97, RMSD 1.61 Å
- 3NR9 chain A against the predicted model P49760: TM-score 0.97, RMSD 1.61 Å
- 6FYK chain C against the predicted model P49760: TM-score 0.97, RMSD 1.67 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.