MolNFT v1 · #136245 · protein

Structure of TNRC6A nls in complex with importin-alpha

5UMZ · Importin subunit alpha-1: “Structure of TNRC6A nls in complex with importin-alpha”. X-ray diffraction, 1 pocket (best druggability 0.48). MolNFT v1 #136245 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5UMZ
Type: protein
Length: 440 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; TNRC6A
UniProt: P52293
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 3 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Importin subunit alpha-1	protein	426	74% helix, 0% strand	P52293
E	TNRC6A	protein	6	0% helix, 0% strand	—
D	TNRC6A	protein	8	0% helix, 0% strand	—

Ligands and binding sites

GOL · Glycerol · additive · 4 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.48	0.83	12	GOL

Interfaces

2 interfaces between chains.

B–D · 694 Å² buried · 22 hydrogen bonds · protein-protein
B–E · 596 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

5UMZ · Structure of TNRC6A NLS in complex with importin-alpha · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Elsewhere: RCSB PDB 5UMZ · PDBe 5UMZ · UniProt P52293

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