MolNFT v1 · #136217 · protein

Crystal structure of the F255A mutant KIR3.1 cytoplasmic pore domain

5UM4 · G protein-activated inward rectifier potassium channel 1: “Crystal structure of the F255A mutant KIR3.1 cytoplasmic pore domain”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #136217 on GenesisL1: 3D structure…

PDB: 5UM4
Type: protein
Length: 197 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: G protein-activated inward rectifier potassium channel 1
UniProt: H9GIV0, P63250
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	G protein-activated inward rectifier potassium channel 1	protein	197	12% helix, 41% strand	H9GIV0, P63250

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	132	0.51	0.80	18	empty
2	56	0.26	0.73	22	empty

Modifications

Observed in the structure: 2 modified (artifact).

Compared structures

5UM4 · Crystal structure of the F255A mutant Kir3.1 cytoplasmic pore domain · the same entry in another collection · chain A against A, TM-score 1.00
P63250 · AlphaFold monomer V2.0 prediction for G protein-activated inward rectifier potassium… · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H9GIV0
Every structure of UniProt P63250
Elsewhere: RCSB PDB 5UM4 · PDBe 5UM4 · UniProt H9GIV0 · UniProt P63250

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