MolNFT v1 · #136157 · protein
The co-structure of (R)-4-(6-(1-(CYCLOPROPYLSULFONYL)CYCLOPROPYL)-2- (1H-indol-4-YL)PYRIMIDIN-4-yl)-3-methylmorpholine and a rationally designed PI3K-alpha mutant that mimics atr
5UK8: “The co-structure of (R)-4-(6-(1-(CYCLOPROPYLSULFONYL)CYCLOPROPYL)-2…”. X-ray diffraction, 1 ligand (8DV). MolNFT v1 #136157 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5UK8
- Type
- protein
- Length
- 1,252 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P42336, P27986
- Ligands
- 8DV
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1008 | — | P42336 |
| B | — | protein | 244 | — | P27986 |
Ligands and binding sites
- 8DV · (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5UK8 · The co-structure of (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimid… · the same entry in another collection · chain A against A, TM-score 1.00
- P42336 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42336
- Every structure of UniProt P27986
- Elsewhere: RCSB PDB 5UK8 · PDBe 5UK8 · UniProt P42336 · UniProt P27986
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