MolNFT v1 · #136050 · protein

Crystal structure of BETA'MTBSI of mycobacterium tuberculosis RNA polymerase

5UH7 · DNA-directed RNA polymerase subunit beta': “Crystal structure of BETA'MTBSI of mycobacterium tuberculosis RNA polymerase”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #136050 on GenesisL1: 3D structure, binding…

PDB: 5UH7
Type: protein
Length: 264 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA-directed RNA polymerase subunit beta'
EC: 2.7.7.6
UniProt: P9WGY7
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA-directed RNA polymerase subunit beta' (EC 2.7.7.6)	protein	131	74% helix, 9% strand	P9WGY7
B	DNA-directed RNA polymerase subunit beta' (EC 2.7.7.6)	protein	133	71% helix, 9% strand	P9WGY7

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	120	0.42	0.76	17	empty
2	56	0.32	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 339 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5UH7 · Crystal structure of beta'MtbSI of Mycobacterium tuberculosis RNA polymerase · the same entry in another collection · chain A against A, TM-score 1.00
P9WGY7 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta' (P9WGY7) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WGY7
Elsewhere: RCSB PDB 5UH7 · PDBe 5UH7 · UniProt P9WGY7

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