MolNFT v1 · #136043 · protein
Structure of the human telomerase thumb domain
5UGW · Telomerase reverse transcriptase: “Structure of the human telomerase thumb domain”. X-ray diffraction, 1 ligand (GSH), 2 pockets (best druggability 0.32). MolNFT v1 #136043 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5UGW
- Type
- protein
- Length
- 158 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase reverse transcriptase
- EC
- 2.7.7.49
- UniProt
- O14746
- Ligands
- GSH
- Pockets
- 2 · best druggability 0.32
Structure
x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 158 | 73% helix, 0% strand | O14746 |
Ligands and binding sites
- GSH · Glutathione · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.32 | 0.74 | 15 | empty |
| 2 | 54 | 0.27 | 0.73 | 10 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14746
- Elsewhere: RCSB PDB 5UGW · PDBe 5UGW · UniProt O14746
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