MolNFT v1 · #136028 · protein
Crystal structure of MAT2A bound to the allosteric inhibitor pf- 02929366
5UGH: “Crystal structure of MAT2A bound to the allosteric inhibitor pf- 02929366”. X-ray diffraction, 1 ligand (8AJ). MolNFT v1 #136028 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5UGH
- Type
- protein
- Length
- 1,468 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P31153
- Ligands
- 8AJ
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 369 | — | P31153 |
| B | — | protein | 365 | — | P31153 |
| C | — | protein | 368 | — | P31153 |
| D | — | protein | 366 | — | P31153 |
Ligands and binding sites
- 8AJ · 2-(7-chloro-5-phenyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine · ligand · 4 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5UGH · Crystal structure of Mat2a bound to the allosteric inhibitor PF-02929366 · the same entry in another collection · chain D against D, TM-score 1.00
- P31153 · AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase isoform type-2… · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31153
- Elsewhere: RCSB PDB 5UGH · PDBe 5UGH · UniProt P31153
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