Structure of the dominant negative mutant glucocorticoid receptor alpha (L733K/N734P) complexed with ru-486

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• 486 · 11-(4-dimethylamino-phenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodec ahydro-cyclopenta[a]phenanthren-3-one · ligand · 2 copies · chains A, B
• EDO · 1,2-ethanediol · additive · 9 copies · chains A, B
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · 3 copies · chains A, B
• EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5UC3 · Structure of the dominant negative mutant Glucocorticoid Receptor alpha (L733K/N734P)… · the same entry in another collection · chain A against A, TM-score 1.00
• P04150 · AlphaFold monomer V2.0 prediction for glucocorticoid receptor (P04150) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P04150
• Elsewhere: RCSB PDB 5UC3 · PDBe 5UC3 · UniProt P04150