MolNFT v1 · #135788 · protein

Crystal structure of the fkbp domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) complexed with S- farnesyl-L-cysteine methyl ester

5U9I: “Crystal structure of the fkbp domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1)…”. X-ray diffraction, 1 ligand (FAR), 2 pockets (best druggability 0.70). MolNFT v1 #135788 on GenesisL1: 3D structure…

PDB: 5U9I
Type: protein
Length: 150 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1)
UniProt: Q9NZN9
Ligands: FAR
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1)	protein	150	31% helix, 29% strand	Q9NZN9

Ligands and binding sites

FAR · Farnesyl · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	175	0.70	0.87	24	FAR
2	70	0.38	0.78	17	empty

Compared structures

5U9I · Crystal structure of the FKBP domain of human aryl hydrocarbon receptor-interacting… · the same entry in another collection · chain A against A, TM-score 1.00
Q9NZN9 · AlphaFold monomer V2.0 prediction for aryl-hydrocarbon-interacting protein-like 1 (Q9NZN9) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NZN9
Elsewhere: RCSB PDB 5U9I · PDBe 5U9I · UniProt Q9NZN9

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